X-ray solution scattering studies of protein folding
نویسندگان
چکیده
منابع مشابه
Studies of Protein Structure in Solution and Protein Folding Using Synchrotron Small-angle X-ray Scattering
Synchrotron small angle x-ray scattering (SAXS) has been applied to the structural study of several biological systems, including the nitrogenase complex, the heat shock cognate protein (hsc70), and lysozyme folding. The structural information revealed from the SAXS experiments is complementary to information obtained by other physical and biochemical methods, and adds to our knowledge and unde...
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iv Acknowledgments V Table of
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We propose a computationally effective approach that builds on Landau mean-field theory in combination with modern nonequilibrium statistical mechanics to model and interpret protein dynamics and structure formation in small- to wide-angle x-ray scattering (S/WAXS) experiments. We develop the methodology by analyzing experimental data in the case of Engrailed homeodomain protein as an example. ...
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It is becoming increasingly clear that characterization of the protein ensemble-the collection of all conformations of which the protein is capable-will be a critical step in developing a full understanding of the linkage between structure, dynamics, and function. X-ray solution scattering in the small angle (SAXS) and wide-angle (WAXS) regimes represents an important new window to exploring th...
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Generally, a protein molecule should form its native structure to perform its biological function in the living cell. However, the failure of proper folding, i.e. misfolding, occurs occasionally and this causes aggregation and/or degradation of the protein, which is potentially linked to protein mis-folding diseases, e.g. prion disease and Parkinson's disease. Therefore, it is critical to under...
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ژورنال
عنوان ژورنال: Folding and Design
سال: 1996
ISSN: 1359-0278
DOI: 10.1016/s1359-0278(96)00047-8